Commit b22d7ac9 authored by Vesa Oikonen's avatar Vesa Oikonen
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title: Analysis of [C-11]-R-PK11195
author: Vesa Oikonen, Jouni Tuisku
updated_at: 2021-04-27
updated_at: 2021-04-28
created_at: 2007-01-29
tags:
- Inflammation
......@@ -115,6 +115,12 @@ input Logan plot</a>
(<a href="https://doi.org/10.1016/j.neuroimage.2008.09.021">Zhou et al., 2009</a>),
which is less sensitive to noise.</p>
<p>TSPO level in the normal brain is very low, and thus the blood vessel uptake of TSPO ligands
becomes predominant. Vascular component can be included in SRTM as a linear term for both the target
and reference region, increasing the [<sup>11</sup>C]-<em>R</em>-PK11195 <em>BP<sub>ND</sub></em>
difference between AD patients and control subjects
(<a href="https://doi.org/10.2967/jnumed.108.050583">Tomasi et al., 2008</a>).</p>
<h4>Ratio method with white matter as reference tissue</h4>
......
---
title: Mitochondria
author: Vesa Oikonen
updated_at: 2021-04-27
updated_at: 2021-04-28
created_at: 2017-09-20
tags:
- Mitochondria
......@@ -230,7 +230,10 @@ studying the concentration of viable mitochondria in tissues.
For instance, regional uptake of TSPO radioligand
<a href="./analysis_11c-pbr28.html">[<sup>11</sup>C]PBR28</a> was lower in subjects with autism
spectrum disorder in brain regions associated with sociocognitive processes
(<a href="https://doi.org/10.1038/s41380-020-0682-z">Zürcher et al., 2020</a>).</p>
(<a href="https://doi.org/10.1038/s41380-020-0682-z">Zürcher et al., 2020</a>).
Abnormal brain uptake of <a href="./analysis_11c-pk11195.html">[<sup>11</sup>C]-(<em>R</em>)-PK11195</a>
has been seen in patients with mitochondrial disease
(<a href="https://doi.org/10.1212/WNL.0000000000012033">van den Ameele et al., 2021</a>).</p>
<h3>P2X<sub>7</sub>R</h3>
......
---
title: TSPO
author: Vesa Oikonen
updated_at: 2021-04-27
updated_at: 2021-04-28
created_at: 2012-09-14
tags:
- TSPO
......@@ -134,11 +134,19 @@ and the experiences of using this method in Turku have been promising
(Tuisku J, personal communication).</p>
<p>TSPO level in the normal brain is very low, and thus the blood vessel uptake of TSPO ligands
becomes predominant. In case of [<sup>11</sup>C]-(<em>R</em>)-PK11195, also the nonspecific binding
hinders the visualization of low levels of glial activation. In addition, the abundance of TSPO in
peripheral organs affects the availability of PET tracers for binding in the brain
(<a href="https://www.ncbi.nlm.nih.gov/pubmed/17204713">Turkheimer et al., 2007</a>) - displacement
studies with unlabelled PK11195 have even resulted in increased uptake of
becomes predominant. In <a href="./dis_ad.html">AD</a> brain, vascular fibrosis decreases the size
of lumens, reduces <a href="./blood_volume.html">blood volume</a>, and leads to loss of vascular
TSPO, particularly in smooth muscles, as shown by immunohistochemistry
(<a href="https://doi.org/10.2967/jnumed.108.050583">Tomasi et al., 2008</a>).
Vascular component can be included in SRTM as a linear term for both the target and reference region,
increasing the estimated <em>BP<sub>ND</sub></em> difference between AD patients and control subjects
(<a href="https://doi.org/10.2967/jnumed.108.050583">Tomasi et al., 2008</a>).
In case of [<sup>11</sup>C]-(<em>R</em>)-PK11195, also the nonspecific binding
hinders the visualization of low levels of glial activation.</p>
<p>The abundance of TSPO in peripheral organs affects the availability of PET tracers for binding in
the brain (<a href="https://www.ncbi.nlm.nih.gov/pubmed/17204713">Turkheimer et al., 2007</a>) -
displacement studies with unlabelled PK11195 have even resulted in increased uptake of
[<sup>11</sup>C]-(<em>R</em>)-PK11195 in the brain, and blocking studies of [<sup>18</sup>F]FEPPA
and <a href="./analysis_11c-pbr28.html">[<sup>11</sup>C]PBR28</a> based on SUV have failed because
of increased tracer availability with higher mass
......
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