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Commit 1512a3c4 authored by Vesa Oikonen's avatar Vesa Oikonen
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ref; more intro

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title: Analysis of [C-11]-R-PK11195
author: Vesa Oikonen, Jouni Tuisku
updated_at: 2021-04-23
updated_at: 2021-04-27
created_at: 2007-01-29
- Inflammation
......@@ -19,7 +19,11 @@ tags:
<p>PK11195 is a selective ligand for the <a href="./target_tspo.html">translocator protein
(TSPO)</a>, formerly known as peripheral benzodiazepine receptor (PBR).</p>
(TSPO)</a>, formerly known as peripheral benzodiazepine receptor (PBR).
Because of the high lipophilicity of PK11195, a relatively high fraction of measured tissue uptake
is due to nonspecific binding. The second-generation radioligands for TSPO have better
target-to-background ratio, but in humans these show three different binding affinity patterns
caused by <a href="./target_tspo.html##rs6971">rs6971 polymorphism</a>.</p>
......@@ -40,6 +44,12 @@ provided that the range of basis functions is carefully optimized.</p>
arteries in sufficient quality to detect glial activation in <a href="./dis_pd.html">Parkinson's
disease</a> (<a href="">Kang et al., 2018</a>).</p>
<p>In a study of <a href="./dis_ms.html">MS</a> patients and healthy controls, the fractions of
parent radioligand in plasma did not differ between groups, sexes, or treatment categories,
suggesting that <a href="./input_metabolite_correction.html">plasma metabolite correction</a>
could be based on population average
(<a href="">de Souza et al., 2021</a>).</p>
<h4>2-tissue compartment model with plasma input</h4>
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