ref

content/analysis_11c-deprenyl-d2.html

 ---
 title: Analysis of [C-11]L-deprenyl-D2
 author: Vesa Oikonen
-updated_at: 2021-04-19
+updated_at: 2021-04-28
 created_at: 2014-05-19
 tags:
   - MAO B
@@ -16,11 +16,12 @@ tags:
 predominantly in glial cells and in serotonergic neurons 
 (<a href="https://doi.org/10.1007/s11307-005-0016-1">Fowler et al., 2005</a>). 
 The expression of MAO-B in glial cells is thought to be predominantly, if not exclusively, within 
-astrocytes (<a href="https://doi.org/10.1007/978-3-7091-9324-2_33">Ekblom et al., 1994</a>), but not
+astrocytes (<a href="https://doi.org/10.1007/978-3-7091-9324-2_33">Ekblom et al., 1994</a>;
+<a href="https://doi.org/10.1016/j.neuint.2010.10.013">Gulyás et al, 2011</a>), but not
 microglia.</p>
 
-<p>MAO-B oxidises amines (for example <a href="./target_dopamine.html">dopamine</a>) from both 
-endogenous and exogenous sources. 
+<p>MAO-B oxidises amines (for example <a href="./target_dopamine.html">dopamine</a> and 
+noradrenaline) from both endogenous and exogenous sources. 
 MAO-B is selectively and irreversibly inhibited by L-deprenyl (selegiline). 
 When the enzyme-substrate complex is formed, the rate-limiting step of MAO-B catalyzed oxidation 
 creates a highly reactive intermediate, which forms a covalent bond with the enzyme, thus