Commit 2f8e05c6 authored by Vesa Oikonen's avatar Vesa Oikonen
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title: Analysis of [C-11]L-deprenyl-D2 title: Analysis of [C-11]L-deprenyl-D2
author: Vesa Oikonen author: Vesa Oikonen
updated_at: 2021-04-19 updated_at: 2021-04-28
created_at: 2014-05-19 created_at: 2014-05-19
tags: tags:
- MAO B - MAO B
...@@ -16,11 +16,12 @@ tags: ...@@ -16,11 +16,12 @@ tags:
predominantly in glial cells and in serotonergic neurons predominantly in glial cells and in serotonergic neurons
(<a href="https://doi.org/10.1007/s11307-005-0016-1">Fowler et al., 2005</a>). (<a href="https://doi.org/10.1007/s11307-005-0016-1">Fowler et al., 2005</a>).
The expression of MAO-B in glial cells is thought to be predominantly, if not exclusively, within The expression of MAO-B in glial cells is thought to be predominantly, if not exclusively, within
astrocytes (<a href="https://doi.org/10.1007/978-3-7091-9324-2_33">Ekblom et al., 1994</a>), but not astrocytes (<a href="https://doi.org/10.1007/978-3-7091-9324-2_33">Ekblom et al., 1994</a>;
<a href="https://doi.org/10.1016/j.neuint.2010.10.013">Gulyás et al, 2011</a>), but not
microglia.</p> microglia.</p>
<p>MAO-B oxidises amines (for example <a href="./target_dopamine.html">dopamine</a>) from both <p>MAO-B oxidises amines (for example <a href="./target_dopamine.html">dopamine</a> and
endogenous and exogenous sources. noradrenaline) from both endogenous and exogenous sources.
MAO-B is selectively and irreversibly inhibited by L-deprenyl (selegiline). MAO-B is selectively and irreversibly inhibited by L-deprenyl (selegiline).
When the enzyme-substrate complex is formed, the rate-limiting step of MAO-B catalyzed oxidation When the enzyme-substrate complex is formed, the rate-limiting step of MAO-B catalyzed oxidation
creates a highly reactive intermediate, which forms a covalent bond with the enzyme, thus creates a highly reactive intermediate, which forms a covalent bond with the enzyme, thus
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