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Commit e6a47ab9 authored by Vesa Oikonen's avatar Vesa Oikonen
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...@@ -36,7 +36,7 @@ monocarboxylate transporter and <a href="./target_aquaporins.html">aquaporins</a ...@@ -36,7 +36,7 @@ monocarboxylate transporter and <a href="./target_aquaporins.html">aquaporins</a
across cell membranes.</p> across cell membranes.</p>
<p><a href="./pic/acetate-acetylCoA.svg"><img src="./pic/acetate-acetylCoA.svg" <p><a href="./pic/acetate-acetylCoA.svg"><img src="./pic/acetate-acetylCoA.svg"
alt="acetate to acetyl-CoA conversion by ACH" alt="acetate to acetyl-CoA conversion by ACH" title="acetate to acetyl-CoA conversion by ACH"
style="padding:6px 0px 0px 6px; width:350px; float:right;" /></a> style="padding:6px 0px 0px 6px; width:350px; float:right;" /></a>
</p> </p>
...@@ -74,9 +74,9 @@ acetate (<a href="https://doi.org/10.1016/0969-8051(94)90178-3">Kihlberg et al., ...@@ -74,9 +74,9 @@ acetate (<a href="https://doi.org/10.1016/0969-8051(94)90178-3">Kihlberg et al.,
<div class="images"> <div class="images">
<a href="./pic/1-11C-acetate.svg"><img src="./pic/1-11C-acetate.svg" height="80" <a href="./pic/1-11C-acetate.svg"><img src="./pic/1-11C-acetate.svg" height="80"
alt="[1-11C]Acetate" style="padding:0px 10px 0px 0px;" /></a> alt="[1-11C]Acetate" title="[1-11C]Acetate" style="padding:0px 10px 0px 0px;" /></a>
<a href="./pic/2-11C-acetate.svg"><img src="./pic/2-11C-acetate.svg" height="80" <a href="./pic/2-11C-acetate.svg"><img src="./pic/2-11C-acetate.svg" height="80"
alt="[2-11C]Acetate" style="padding:0px 10px 0px 0px;" /></a> alt="[2-11C]Acetate" title="[2-11C]Acetate" style="padding:0px 10px 0px 0px;" /></a>
<p>[1-<sup>11</sup>C]Acetate and [2-<sup>11</sup>C]acetate, labelled into C-1 and C-2 position, <p>[1-<sup>11</sup>C]Acetate and [2-<sup>11</sup>C]acetate, labelled into C-1 and C-2 position,
respectively.</p> respectively.</p>
</div> </div>
...@@ -116,7 +116,8 @@ of astrocytic metabolism in the brain ...@@ -116,7 +116,8 @@ of astrocytic metabolism in the brain
<h2><a name="18F"><sup>18</sup>F-labelled acetate</a></h2> <h2><a name="18F"><sup>18</sup>F-labelled acetate</a></h2>
<p><a href="./pic/18F-fluoroacetate.svg"><img src="./pic/18F-fluoroacetate.svg" <p><a href="./pic/18F-fluoroacetate.svg"><img src="./pic/18F-fluoroacetate.svg"
alt="18F-fluoroacetate" style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a> alt="18F-fluoroacetate" title="18F-fluoroacetate"
style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a>
</p> </p>
<p>The hydrogen atoms of the methyl group can be replaced with <sup>18</sup>F to produce <p>The hydrogen atoms of the methyl group can be replaced with <sup>18</sup>F to produce
...@@ -163,22 +164,6 @@ it with ethanol to increase lipophilicity. The resulting proradiotracer [<sup>18 ...@@ -163,22 +164,6 @@ it with ethanol to increase lipophilicity. The resulting proradiotracer [<sup>18
the brain rapidly and was converted to TCA cycle metabolites the brain rapidly and was converted to TCA cycle metabolites
(<a href="https://doi.org/10.1016/j.nucmedbio.2008.11.006">Mori et al., 2009</a>).</p> (<a href="https://doi.org/10.1016/j.nucmedbio.2008.11.006">Mori et al., 2009</a>).</p>
<!-- Moved into its own page
<p><a href="./pic/2-18F-fluoropropionate.svg"><img src="./pic/2-18F-fluoropropionate.svg"
alt="18F-labelled propionate" style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a>
</p>
<h3><a name="FPA">2-[<sup>18</sup>F]fluoropropionate</a></h3>
<p>2-[<sup>18</sup>F]fluoropropionate is another SCFA radiopharmaceutical that mimics acetate,
and could be used in tumour imaging because of increased fatty acid synthesis
(<a href="https://doi.org/10.2967/jnumed.109.064212">Pillarsetty et al., 2009</a>;
<a href="https://doi.org/10.1177/1536012118821032">Zhao et al., 2019</a>;
Zhang et al., <a href="https://doi.org/10.1007/s11307-019-01346-1">2019</a> and
<a href="https://doi.org/10.1007/s11307-021-01608-x">2021</a>).</p>
-->
<br> <br>
<h2>See also:</h2> <h2>See also:</h2>
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...@@ -12,7 +12,7 @@ tags: ...@@ -12,7 +12,7 @@ tags:
<h1>Quantification of [<sup>11</sup>C]PBR28 PET studies</h1> <h1>Quantification of [<sup>11</sup>C]PBR28 PET studies</h1>
<p><a href="./pic/11C-PBR28.svg"><img src="./pic/11C-PBR28.svg" alt="11C-PBR28" <p><a href="./pic/11C-PBR28.svg"><img src="./pic/11C-PBR28.svg" alt="11C-PBR28" title="11C-PBR28"
style="padding:10px 0px 0px 10px; width:150px; float:right;" /></a> style="padding:10px 0px 0px 10px; width:150px; float:right;" /></a>
</p> </p>
......
...@@ -13,7 +13,7 @@ tags: ...@@ -13,7 +13,7 @@ tags:
<h1>Analysis of [<sup>11</sup>C]PIB PET data</h1> <h1>Analysis of [<sup>11</sup>C]PIB PET data</h1>
<div> <div>
<p><a href="./pic/11C-PIB.svg"><img src="./pic/11C-PIB.svg" alt="11C-PIB" <p><a href="./pic/11C-PIB.svg"><img src="./pic/11C-PIB.svg" alt="11C-PIB" title="11C-PIB"
style="padding:10px 0px 0px 10px; width:200px; float:right;" /></a> style="padding:10px 0px 0px 10px; width:200px; float:right;" /></a>
</p> </p>
......
...@@ -14,7 +14,7 @@ tags: ...@@ -14,7 +14,7 @@ tags:
<div> <div>
<p><a href="./pic/11C-PK11195.svg"><img src="./pic/11C-PK11195.svg" alt="11C-PK11195" <p><a href="./pic/11C-PK11195.svg"><img src="./pic/11C-PK11195.svg" alt="11C-PK11195" title="11C-PK11195"
style="padding:10px 0px 0px 10px; width:150px; float:right;" /></a> style="padding:10px 0px 0px 10px; width:150px; float:right;" /></a>
</p> </p>
......
...@@ -13,7 +13,7 @@ tags: ...@@ -13,7 +13,7 @@ tags:
<p><a href="./pic/11C-SMW139.svg"> <p><a href="./pic/11C-SMW139.svg">
<img src="./pic/11C-SMW139.svg" alt="[C-11]SMW139" <img src="./pic/11C-SMW139.svg" alt="[C-11]SMW139" title="[C-11]SMW139"
style="padding:10px 0px 0px 10px; width:200px; float:right;" /> style="padding:10px 0px 0px 10px; width:200px; float:right;" />
</a></p> </a></p>
......
...@@ -13,7 +13,7 @@ tags: ...@@ -13,7 +13,7 @@ tags:
<p><a name="fig1"></a> <p><a name="fig1"></a>
<a href="./pic/(C-11)UCB-J.svg"> <a href="./pic/(C-11)UCB-J.svg">
<img src="./pic/(C-11)UCB-J.svg" alt="[C-11]UCB-J" <img src="./pic/(C-11)UCB-J.svg" alt="[C-11]UCB-J" title="[C-11]UCB-J"
style="padding:10px 0px 0px 10px; width:180px; float:right;" /> style="padding:10px 0px 0px 10px; width:180px; float:right;" />
</a></p> </a></p>
......
...@@ -7,7 +7,7 @@ tags: ...@@ -7,7 +7,7 @@ tags:
- Hypoxia - Hypoxia
--- ---
<p><a href="./pic/18F-EF5.svg"><img src="./pic/18F-EF5.svg" alt="F-18 labelled EF5" <p><a href="./pic/18F-EF5.svg"><img src="./pic/18F-EF5.svg" alt="F-18 labelled EF5" title="F-18 labelled EF5"
style="padding:10px 0px 0px 10px; width:180px; float:right;" /></a></p> style="padding:10px 0px 0px 10px; width:180px; float:right;" /></a></p>
<h1>[<sup>18</sup>F]EF5 PET</h1> <h1>[<sup>18</sup>F]EF5 PET</h1>
......
...@@ -33,9 +33,9 @@ The effective dose from [<sup>18</sup>F]FBPA PET study is similar than that of ...@@ -33,9 +33,9 @@ The effective dose from [<sup>18</sup>F]FBPA PET study is similar than that of
<figure style="border: 1px solid #000;"> <figure style="border: 1px solid #000;">
<a href="./pic/L-BPA.svg"> <a href="./pic/L-BPA.svg">
<img style="width:250px; margin: 0.5em;" src="./pic/L-BPA.svg" alt="L-BPA"></a> <img style="width:250px; margin: 0.5em;" src="./pic/L-BPA.svg" alt="L-BPA" title="L-BPA"></a>
<a href="./pic/(F-18)FBPA.svg"> <a href="./pic/(F-18)FBPA.svg">
<img style="width:250px; margin: 0.5em;" src="./pic/(F-18)FBPA.svg" alt="FBPA"></a> <img style="width:250px; margin: 0.5em;" src="./pic/(F-18)FBPA.svg" alt="FBPA" title="FBPA"></a>
<figcaption style="margin: 0.5em;"><strong>L-BPA and [<sup>18</sup>F]FBPA</strong> <figcaption style="margin: 0.5em;"><strong>L-BPA and [<sup>18</sup>F]FBPA</strong>
</figcaption> </figcaption>
</figure> </figure>
...@@ -228,10 +228,6 @@ the <sup>10</sup>B in organs (normal tissues) by simply multiplying the relative ...@@ -228,10 +228,6 @@ the <sup>10</sup>B in organs (normal tissues) by simply multiplying the relative
[<sup>18</sup>F]FBPA per g tissue by the therapeutic dose (g) of L-BPA, neglecting possible [<sup>18</sup>F]FBPA per g tissue by the therapeutic dose (g) of L-BPA, neglecting possible
saturation effects from the much higher mass of the L-BPA dose.</p> saturation effects from the much higher mass of the L-BPA dose.</p>
<--
-->
<br> <br>
<h2>See also:</h2> <h2>See also:</h2>
......
...@@ -17,9 +17,11 @@ tags: ...@@ -17,9 +17,11 @@ tags:
<figure style="border: 1px solid #000;"> <figure style="border: 1px solid #000;">
<a href="./pic/norepinephrine.svg"> <a href="./pic/norepinephrine.svg">
<img style="width:220px; margin: 0.5em;" src="./pic/norepinephrine.svg" alt="Norepinephrine"></a> <img style="width:220px; margin: 0.5em;" src="./pic/norepinephrine.svg"
alt="Norepinephrine" title="Norepinephrine"></a>
<a href="./pic/6-18F-FDA.svg"> <a href="./pic/6-18F-FDA.svg">
<img style="width:220px; margin: 0.5em;" src="./pic/6-18F-FDA.svg" alt="6-[F-18]-FDA"></a> <img style="width:220px; margin: 0.5em;" src="./pic/6-18F-FDA.svg"
alt="6-[F-18]-FDA" title="6-[F-18]-FDA"></a>
<figcaption style="margin: 0.5em;">Norepinephrine (noradrenaline) and <figcaption style="margin: 0.5em;">Norepinephrine (noradrenaline) and
6-[<sup>18</sup>F]fluorodopamine (6-[<sup>18</sup>F]FDA) 6-[<sup>18</sup>F]fluorodopamine (6-[<sup>18</sup>F]FDA)
</figcaption> </figcaption>
......
...@@ -19,8 +19,8 @@ tags: ...@@ -19,8 +19,8 @@ tags:
<h1>Quantification of metabolic rate of glucose uptake with [<sup>18</sup>F]FDG</h1> <h1>Quantification of metabolic rate of glucose uptake with [<sup>18</sup>F]FDG</h1>
<p><a href="./pic/(F-18)fdg.svg"> <p><a href="./pic/(F-18)fdg.svg">
<img src="./pic/(F-18)fdg.svg" alt="2-[F-18]fluoro-2-deoxy-D-glucose" <img src="./pic/(F-18)fdg.svg" style="padding:10px 0px 0px 10px; width:200px; float:right;"
style="padding:10px 0px 0px 10px; width:200px; float:right;" /> alt="2-[F-18]fluoro-2-deoxy-D-glucose" title="2-[F-18]fluoro-2-deoxy-D-glucose" />
</a></p> </a></p>
<p>[<sup>18</sup>F]2-fluoro-2-deoxy-D-glucose ([<sup>18</sup>F]FDG) is a <a href="./glucose.html" <p>[<sup>18</sup>F]2-fluoro-2-deoxy-D-glucose ([<sup>18</sup>F]FDG) is a <a href="./glucose.html"
......
...@@ -32,9 +32,9 @@ and [<sup>18</sup>F]FPDOPA ...@@ -32,9 +32,9 @@ and [<sup>18</sup>F]FPDOPA
<figure style="border: 1px solid #000;"> <figure style="border: 1px solid #000;">
<a href="./pic/L-DOPA.svg"> <a href="./pic/L-DOPA.svg">
<img style="width:250px; margin: 0.5em;" src="./pic/L-DOPA.svg" alt="L-DOPA"></a> <img style="width:250px; margin: 0.5em;" src="./pic/L-DOPA.svg" alt="L-DOPA" title="L-DOPA"></a>
<a href="./pic/6-(F-18)FDOPA.svg"> <a href="./pic/6-(F-18)FDOPA.svg">
<img style="width:250px; margin: 0.5em;" src="./pic/6-(F-18)FDOPA.svg" alt="FDOPA"></a> <img style="width:250px; margin: 0.5em;" src="./pic/6-(F-18)FDOPA.svg" alt="FDOPA" title="FDOPA"></a>
<figcaption style="margin: 0.5em;"><strong>L-DOPA and 6-[<sup>18</sup>F]FDOPA</strong> <figcaption style="margin: 0.5em;"><strong>L-DOPA and 6-[<sup>18</sup>F]FDOPA</strong>
</figcaption> </figcaption>
</figure> </figure>
......
...@@ -12,7 +12,7 @@ tags: ...@@ -12,7 +12,7 @@ tags:
<h1>(2<em>S</em>,4<em>R</em>)-4-[<sup>18</sup>F]fluoroglutamine</h1> <h1>(2<em>S</em>,4<em>R</em>)-4-[<sup>18</sup>F]fluoroglutamine</h1>
<div><a href="./pic/2S4R-4-18F-FGln.png"><img src="./pic/2S4R-4-18F-FGln.png" <div><a href="./pic/2S4R-4-18F-FGln.png"><img src="./pic/2S4R-4-18F-FGln.png"
alt="(2S,4R)-4-[18F]fluoroglutamine" alt="(2S,4R)-4-[18F]fluoroglutamine" title="(2S,4R)-4-[18F]fluoroglutamine"
style="padding:10px 0px 0px 10px; width:200px; float:right;" /></a></div> style="padding:10px 0px 0px 10px; width:200px; float:right;" /></a></div>
<p><a href="./glutamine.html">L-Glutamine</a> (Gln) has many important functions in <p><a href="./glutamine.html">L-Glutamine</a> (Gln) has many important functions in
......
...@@ -13,7 +13,8 @@ tags: ...@@ -13,7 +13,8 @@ tags:
<p><a href="./pic/2-18F-fluoropropionate.svg"><img src="./pic/2-18F-fluoropropionate.svg" <p><a href="./pic/2-18F-fluoropropionate.svg"><img src="./pic/2-18F-fluoropropionate.svg"
alt="18F-labelled propionate" style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a> alt="18F-labelled propionate" title="18F-labelled propionate"
style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a>
</p> </p>
<p>2-[<sup>18</sup>F]fluoropropionate (2-[<sup>18</sup>F]fluoropropionic acid, [<sup>18</sup>F]FPA) <p>2-[<sup>18</sup>F]fluoropropionate (2-[<sup>18</sup>F]fluoropropionic acid, [<sup>18</sup>F]FPA)
......
...@@ -8,7 +8,7 @@ tags: ...@@ -8,7 +8,7 @@ tags:
- Cannabinoids - Cannabinoids
--- ---
<div><a href="./pic/18F-FPATPP.png"><img src="./pic/18F-FPATPP.png" alt="[18F]FPATPP" <div><a href="./pic/18F-FPATPP.png"><img src="./pic/18F-FPATPP.png" alt="[18F]FPATPP" title="[18F]FPATPP"
style="padding:10px 0px 0px 10px; width:260px; float:right;" /></a></div> style="padding:10px 0px 0px 10px; width:260px; float:right;" /></a></div>
<h1>[<sup>18</sup>F]FPATPP PET</h1> <h1>[<sup>18</sup>F]FPATPP PET</h1>
......
...@@ -11,7 +11,8 @@ tags: ...@@ -11,7 +11,8 @@ tags:
<h1>[<sup>18</sup>F]FPIA PET</h1> <h1>[<sup>18</sup>F]FPIA PET</h1>
<p><a href="./pic/18F-FPIA.svg"><img src="./pic/18F-FPIA.svg" <p><a href="./pic/18F-FPIA.svg"><img src="./pic/18F-FPIA.svg"
alt="18F-labelled pivalate" style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a> alt="18F-labelled pivalate" title="18F-labelled pivalate"
style="padding:6px 0px 0px 6px; width:100px; float:right;" /></a>
</p> </p>
<p>[<sup>18</sup>F]Fluoro-pivalic acid ([<sup>18</sup>F]FPIA) is based on a non-natural <p>[<sup>18</sup>F]Fluoro-pivalic acid ([<sup>18</sup>F]FPIA) is based on a non-natural
......
...@@ -33,11 +33,14 @@ is safer, allows same-day imaging, and better image quality than what is possibl ...@@ -33,11 +33,14 @@ is safer, allows same-day imaging, and better image quality than what is possibl
<figure style="border: 1px solid #000;"> <figure style="border: 1px solid #000;">
<a href="./pic/norepinephrine.svg"> <a href="./pic/norepinephrine.svg">
<img style="width:160px; margin: 0.5em;" src="./pic/norepinephrine.svg" alt="Noradrenaline"></a> <img style="width:160px; margin: 0.5em;" src="./pic/norepinephrine.svg"
alt="Noradrenaline" title="Noradrenaline"></a>
<a href="./pic/123I-MIBG.svg"> <a href="./pic/123I-MIBG.svg">
<img style="width:200px; margin: 0.5em;" src="./pic/123I-MIBG.svg" alt="[I-123]MIBG"></a> <img style="width:200px; margin: 0.5em;" src="./pic/123I-MIBG.svg"
alt="[I-123]MIBG" title="[I-123]MIBG"></a>
<a href="./pic/18F-MFBG.svg"> <a href="./pic/18F-MFBG.svg">
<img style="width:200px; margin: 0.5em;" src="./pic/18F-MFBG.svg" alt="[F-18]MFBG"></a> <img style="width:200px; margin: 0.5em;" src="./pic/18F-MFBG.svg"
alt="[F-18]MFBG" title="[F-18]MFBG"></a>
<figcaption style="margin: 0.5em;">Noradrenaline, [<sup>123</sup>I]MIBG, and [<sup>18</sup>F]MFBG <figcaption style="margin: 0.5em;">Noradrenaline, [<sup>123</sup>I]MIBG, and [<sup>18</sup>F]MFBG
</figcaption> </figcaption>
</figure> </figure>
......
...@@ -9,7 +9,8 @@ tags: ...@@ -9,7 +9,8 @@ tags:
--- ---
<div><a href="./pic/18F-PSMA-1007.svg"><img src="./pic/18F-PSMA-1007.svg" alt="[18F]PSMA-1007" <div><a href="./pic/18F-PSMA-1007.svg"><img src="./pic/18F-PSMA-1007.svg"
alt="[18F]PSMA-1007" title="[18F]PSMA-1007"
style="padding:10px 0px 0px 10px; width:300px; float:right;" /></a></div> style="padding:10px 0px 0px 10px; width:300px; float:right;" /></a></div>
...@@ -117,7 +118,6 @@ was 0.05&plusmn;0.02 min<sup>-1</sup> in prostate cancer lesions; ...@@ -117,7 +118,6 @@ was 0.05&plusmn;0.02 min<sup>-1</sup> in prostate cancer lesions;
0.09&plusmn;0.08, 0.15&plusmn;0.08, and 0.04&plusmn;0.02 in bone metastases; 0.09&plusmn;0.08, 0.15&plusmn;0.08, and 0.04&plusmn;0.02 in bone metastases;
median <em>k<sub>3</sub></em> was 35-fold higher than <em>k<sub>4</sub></em> in prostate cancer median <em>k<sub>3</sub></em> was 35-fold higher than <em>k<sub>4</sub></em> in prostate cancer
lesions (<a href="https://doi.org/10.1007/s00259-019-04569-0">Sachpekidis et al., 2020</a>). lesions (<a href="https://doi.org/10.1007/s00259-019-04569-0">Sachpekidis et al., 2020</a>).
</p> </p>
<h3>Mass effect</h3> <h3>Mass effect</h3>
......
...@@ -47,7 +47,7 @@ this highly useful technique. Accelerator-based neutron sources are being develo ...@@ -47,7 +47,7 @@ this highly useful technique. Accelerator-based neutron sources are being develo
<div> <div>
<a href="./pic/L-BPA.svg"> <a href="./pic/L-BPA.svg">
<img src="./pic/L-BPA.svg" alt="L-BPA" <img src="./pic/L-BPA.svg" alt="L-BPA" title="L-BPA"
style="padding:8px 0px 0px 8px; width:180px; float:right;" /></a> style="padding:8px 0px 0px 8px; width:180px; float:right;" /></a>
<p>Numerous boron carriers have been developed and studied, and two, <p>Numerous boron carriers have been developed and studied, and two,
......
...@@ -10,7 +10,7 @@ tags: ...@@ -10,7 +10,7 @@ tags:
<p> <p>
<a href="./pic/citrate.svg"> <a href="./pic/citrate.svg">
<img src="./pic/citrate.svg" alt="citrate ion" <img src="./pic/citrate.svg" alt="citrate ion" title="citrate ion"
style="padding:10px 0px 0px 10px; width:180px; float:right;" /> style="padding:10px 0px 0px 10px; width:180px; float:right;" />
</a> </a>
</p> </p>
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...@@ -16,7 +16,7 @@ tags: ...@@ -16,7 +16,7 @@ tags:
<p> <p>
<a href="./pic/D-glucose.svg"> <a href="./pic/D-glucose.svg">
<img src="./pic/D-glucose.svg" alt="D-Glucose" <img src="./pic/D-glucose.svg" alt="D-Glucose" title="D-Glucose"
style="padding:10px 0px 0px 10px; width:200px; float:right;" /> style="padding:10px 0px 0px 10px; width:200px; float:right;" />
</a> </a>
</p> </p>
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