Commit 6ca77aef authored by Vesa Oikonen's avatar Vesa Oikonen
Browse files


parent ea8b0f35
Pipeline #41541 passed with stages
in 56 seconds
title: TSPO
author: Vesa Oikonen
updated_at: 2021-04-28
updated_at: 2021-06-07
created_at: 2012-09-14
......@@ -34,7 +34,9 @@ In the brain parenchyma TSPO is located in glial cells (microglia and astrocytes
used as a biomarker of activated glial cells
(<a href="">Chen &amp; Guilarte, 2008</a>;
<a href="">Alam et al., 2017</a>;
<a href="">Nomura et al., 2021</a>).
<a href="">Nomura et al., 2021</a>), but it is present
also in the neurovascular unit, including endothelial cells, smooth muscle cells, and red blood
cells (<a href="">Wimberley et al., 2021</a>).
Mitochondrial dysfunction or abnormal microglia autophagy may be seen as reduced TSPO expression
(<a href="">Zürcher et al., 2020</a>).
Outside of the brain, TSPO is expressed in macrophages, and could be targeted in
......@@ -129,9 +131,9 @@ model of MS</a>, the healthy hemisphere can be used as reference region
model</a> (SRTM) can be applied, although an ideal <a href="./model_reference_tissue.html">reference
tissue</a> (containing no TSPO) is not available. A clustering method has been introduced to produce
a reference curve for brain [<sup>11</sup>C]-(<em>R</em>)-PK11195 studies
(<a href="">Turkheimer et al., 2007</a>),
and the experiences of using this method in Turku have been promising
(Tuisku J, personal communication).</p>
(<a href="">Turkheimer et al., 2007</a>).
<a href="">Wimberley et al (2021)</a> have reviewed the
brain TSPO quantification methods and their limitations.</p>
<p>TSPO level in the normal brain is very low, and thus the blood vessel uptake of TSPO ligands
becomes predominant. In <a href="./dis_ad.html">AD</a> brain, vascular fibrosis decreases the size
......@@ -279,4 +281,9 @@ The methodology of TSPO imaging with positron emission tomography.
<em>Biochem Soc Trans.</em> 2015; 43: 586-592.
doi: <a href="">10.1042/BST20150058</a>.</p>
<p>Wimberley C, Lavisse S, Hillmer A, Hinz R, Turkheimer F, Zanotti-Fregonara P.
Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain.
<em>Eur J Nucl Med Mol Imaging</em> 2021 (in press).
doi: <a href="">10.1007/s00259-021-05248-9</a>.</p>
Markdown is supported
0% or .
You are about to add 0 people to the discussion. Proceed with caution.
Finish editing this message first!
Please register or to comment