ref

content/analysis_82rb.html

 ---
 title: Analysis of Rb-82
 author: Vesa Oikonen, Chunlei Han
-updated_at: 2021-03-30
+updated_at: 2021-06-03
 created_at: 2009-03-17
 tags:
   - Perfusion
@@ -205,7 +205,9 @@ The method has also been used in rat model of CNS-induced natriuresis
 (<a href="https://doi.org/10.1111/1754-9485.12079">Tahari et al., 2014</a>).
 The high urinary excretion of [<sup>82</sup>Rb]Rb<sup>+</sup> in some patients may hamper the
 assessment of RBF (<a href="https://doi.org/10.1007/s13139-020-00637-8">Jochumsen et al., 2020</a>).
-</p>
+Regadenoson increases and adenosine decreases renal perfusion as measured using 
+[<sup>82</sup>Rb]Rb<sup>+</sup>
+(<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).</p>
 
 
 

content/organ_liver.html

 ---
 title: Liver
 author: Vesa Oikonen
-updated_at: 2020-10-15
+updated_at: 2021-06-03
 created_at: 2015-02-05
 tags:
   - Liver
@@ -57,6 +57,8 @@ content is in the liver.
 <a href="./target_adrenergic_system.html#sympathetic">Sympathetic nerve</a> stimulation and 
 adrenergic and angiotensin agonists can expel 50-60% of this blood from liver in 90 s leading to 
 noticeable shrinkage of the liver and reduced blood flow. 
+Adenosine and regadenoson increase hepatic arterial perfusion
+(<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).
 Since all the blood from the abdominal visceral organs and gastrointestinal tract is drained via 
 the portal vein, the hormones released by these organs, such as 
 <a href="./target_insulin.html">insulin</a> or <a href="./target_glucagon.html">glucagon</a> 
@@ -297,6 +299,9 @@ Portal flow, when adjusted with total liver volume, has been used to assess spla
 <p>[<sup>13</sup>N]NH<sub>4</sub><sup>+</sup> can be used to quantify arterial perfusion in 
 the liver (<a href="https://www.ncbi.nlm.nih.gov/pubmed/1744703">Chen et al., 1991</a>); arterial 
 perfusion in dogs was 40 mL/(min&times;100g) and in healthy humans 26 &plusmn; 7 mL/(min&times;100g).
+
+Also <a href="./analysis_82rb.html">[<sup>82</sup>Rb]Rb<sup>+</sup></a> has been to estimate arterial 
+perfusion in the liver (<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).
 </p> 
 
 

content/organ_spleen.html

 ---
 title: Spleen
 author: Vesa Oikonen
-updated_at: 2018-10-10
+updated_at: 2021-06-03
 created_at: 2016-02-08
 tags:
   - Spleen
@@ -17,6 +17,7 @@ tags:
 <p>The spleen in humans is an oval-shaped organ with size of about 12-15 &times; 4-8 &times; 3-4 cm, 
 weighting usually 100-200 grams (ex vivo; in vivo weight is probably higher). Size of the spleen 
 is very variable between individuals, and accessory spleens are very common.
+The size of spleen varies according to blood flow.
 Spleen is soft, and pushed against diaphragm by the stomach, 
 left <a href="./organ_kidney.html">kidney</a>, tail of <a href="./organ_pancreas.html">pancreas</a>, 
 and left flexure of colon.
@@ -87,17 +88,18 @@ about 30-40% is observed after maximal breath holding in humans
 (<a href="https://doi.org/10.1152/japplphysiol.00055.2001">Espersen et al., 2002</a>).
 <a href="./hematocrit.html">Hematocrit</a> increases subsequently 
 (<a href="https://doi.org/10.1152/jappl.1993.74.3.1024">Laub et al., 1993</a>). 
-Pharmacological or exercise stress during <a href="./organ_heart.html#stress">myocardial perfusion 
-imaging</a> (MPI) reduces blood flow to spleen; failure of this response is an indicator of 
+Pharmacological dipyridamol or exercise stress during <a href="./organ_heart.html#stress">myocardial 
+perfusion imaging</a> (MPI) reduces blood flow to spleen; failure of this response is an indicator of 
 insufficient stress, which is a common cause of false-negative MPI
 (<a href="https://doi.org/10.1007/s12350-018-1269-9">Bami et al., 2018</a>).
-</p>
+Regadenoson increases and adenosine decreases perfusion in spleen
+(<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).</p>
 
 <p>Possible spleen contraction which must be taken into account when imaging splenic function.
 High and variable <a href="./hematocrit.html">haematocrit</a> in the spleen prevents quantification 
 of <a href="./blood_volume.html">vascular volume</a> using <a href="./analysis_15o-co.html">labelled 
-carbon monoxide</a>.
-</p>
+carbon monoxide</a>.</p>
+
 
 <h3>Perfusion and metabolism</h3>
 
@@ -111,7 +113,8 @@ Taniguchi et al., <a href="https://www.ncbi.nlm.nih.gov/pubmed/7699448">1995</a>
 <a href="https://doi.org/10.1158/1535-7163.MCT-08-1016">Kötz et al, 2009</a>).
 Kötz et al. (<a href="https://doi.org/10.1158/1535-7163.MCT-08-1016">2009</a>) reported range 
 0.84-0.96 for partition coefficient of water, and 1.03-1.96 mL/(min mL) for blood flow in the spleen.
-</p> 
+Also <a href="./analysis_82rb.html">[<sup>82</sup>Rb]Rb<sup>+</sup></a> has been to estimate perfusion
+in the spleen (<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).</p> 
 
 <p>Glucose metabolism in the spleen can be studied with [<sup>18</sup>F]FDG
 (<a href="https://www.ncbi.nlm.nih.gov/pubmed/10492365">Sugawara et al., 1999</a>;