Commit 678f3f2f authored by Vesa Oikonen's avatar Vesa Oikonen
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---
title: Analysis of Rb-82
author: Vesa Oikonen, Chunlei Han
updated_at: 2021-03-30
updated_at: 2021-06-03
created_at: 2009-03-17
tags:
- Perfusion
......@@ -205,7 +205,9 @@ The method has also been used in rat model of CNS-induced natriuresis
(<a href="https://doi.org/10.1111/1754-9485.12079">Tahari et al., 2014</a>).
The high urinary excretion of [<sup>82</sup>Rb]Rb<sup>+</sup> in some patients may hamper the
assessment of RBF (<a href="https://doi.org/10.1007/s13139-020-00637-8">Jochumsen et al., 2020</a>).
</p>
Regadenoson increases and adenosine decreases renal perfusion as measured using
[<sup>82</sup>Rb]Rb<sup>+</sup>
(<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).</p>
......
---
title: Liver
author: Vesa Oikonen
updated_at: 2020-10-15
updated_at: 2021-06-03
created_at: 2015-02-05
tags:
- Liver
......@@ -57,6 +57,8 @@ content is in the liver.
<a href="./target_adrenergic_system.html#sympathetic">Sympathetic nerve</a> stimulation and
adrenergic and angiotensin agonists can expel 50-60% of this blood from liver in 90 s leading to
noticeable shrinkage of the liver and reduced blood flow.
Adenosine and regadenoson increase hepatic arterial perfusion
(<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).
Since all the blood from the abdominal visceral organs and gastrointestinal tract is drained via
the portal vein, the hormones released by these organs, such as
<a href="./target_insulin.html">insulin</a> or <a href="./target_glucagon.html">glucagon</a>
......@@ -297,6 +299,9 @@ Portal flow, when adjusted with total liver volume, has been used to assess spla
<p>[<sup>13</sup>N]NH<sub>4</sub><sup>+</sup> can be used to quantify arterial perfusion in
the liver (<a href="https://www.ncbi.nlm.nih.gov/pubmed/1744703">Chen et al., 1991</a>); arterial
perfusion in dogs was 40 mL/(min&times;100g) and in healthy humans 26 &plusmn; 7 mL/(min&times;100g).
Also <a href="./analysis_82rb.html">[<sup>82</sup>Rb]Rb<sup>+</sup></a> has been to estimate arterial
perfusion in the liver (<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).
</p>
......
---
title: Spleen
author: Vesa Oikonen
updated_at: 2018-10-10
updated_at: 2021-06-03
created_at: 2016-02-08
tags:
- Spleen
......@@ -17,6 +17,7 @@ tags:
<p>The spleen in humans is an oval-shaped organ with size of about 12-15 &times; 4-8 &times; 3-4 cm,
weighting usually 100-200 grams (ex vivo; in vivo weight is probably higher). Size of the spleen
is very variable between individuals, and accessory spleens are very common.
The size of spleen varies according to blood flow.
Spleen is soft, and pushed against diaphragm by the stomach,
left <a href="./organ_kidney.html">kidney</a>, tail of <a href="./organ_pancreas.html">pancreas</a>,
and left flexure of colon.
......@@ -87,17 +88,18 @@ about 30-40% is observed after maximal breath holding in humans
(<a href="https://doi.org/10.1152/japplphysiol.00055.2001">Espersen et al., 2002</a>).
<a href="./hematocrit.html">Hematocrit</a> increases subsequently
(<a href="https://doi.org/10.1152/jappl.1993.74.3.1024">Laub et al., 1993</a>).
Pharmacological or exercise stress during <a href="./organ_heart.html#stress">myocardial perfusion
imaging</a> (MPI) reduces blood flow to spleen; failure of this response is an indicator of
Pharmacological dipyridamol or exercise stress during <a href="./organ_heart.html#stress">myocardial
perfusion imaging</a> (MPI) reduces blood flow to spleen; failure of this response is an indicator of
insufficient stress, which is a common cause of false-negative MPI
(<a href="https://doi.org/10.1007/s12350-018-1269-9">Bami et al., 2018</a>).
</p>
Regadenoson increases and adenosine decreases perfusion in spleen
(<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).</p>
<p>Possible spleen contraction which must be taken into account when imaging splenic function.
High and variable <a href="./hematocrit.html">haematocrit</a> in the spleen prevents quantification
of <a href="./blood_volume.html">vascular volume</a> using <a href="./analysis_15o-co.html">labelled
carbon monoxide</a>.
</p>
carbon monoxide</a>.</p>
<h3>Perfusion and metabolism</h3>
......@@ -111,7 +113,8 @@ Taniguchi et al., <a href="https://www.ncbi.nlm.nih.gov/pubmed/7699448">1995</a>
<a href="https://doi.org/10.1158/1535-7163.MCT-08-1016">Kötz et al, 2009</a>).
Kötz et al. (<a href="https://doi.org/10.1158/1535-7163.MCT-08-1016">2009</a>) reported range
0.84-0.96 for partition coefficient of water, and 1.03-1.96 mL/(min mL) for blood flow in the spleen.
</p>
Also <a href="./analysis_82rb.html">[<sup>82</sup>Rb]Rb<sup>+</sup></a> has been to estimate perfusion
in the spleen (<a href="https://doi.org/10.1111/cpf.12691">Gregg et al., 2021</a>).</p>
<p>Glucose metabolism in the spleen can be studied with [<sup>18</sup>F]FDG
(<a href="https://www.ncbi.nlm.nih.gov/pubmed/10492365">Sugawara et al., 1999</a>;
......
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