Commit 18e82802 authored by Vesa Oikonen's avatar Vesa Oikonen
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title: Analysis of Rb-82
author: Vesa Oikonen, Chunlei Han
updated_at: 2020-02-20
updated_at: 2021-03-30
created_at: 2009-03-17
tags:
- Perfusion
......@@ -180,8 +180,12 @@ the extraction correction function as published by <a href=
<p>[<sup>82</sup>Rb]Rb<sup>+</sup> can be used for measurement of
<a href="./organ_kidney.html#perfusion">renal blood flow</a> (RBF),
because it is reabsorbed in the tubules of the <a href="./organ_kidney.html">kidney</a>,
mainly in the cortex, so that the remaining activity in the urine is negligible.
because it is reabsorbed in the tubules of the <a href="./organ_kidney.html">kidney</a> like
K<sup>+</sup>, mainly in the cortex, so that the remaining activity in the urine is usually
negligible. Hypokalemia is linked to increased K<sup>+</sup>/Rb<sup>+</sup> excretion and marked
urinary activity of [<sup>82</sup>Rb]Rb<sup>+</sup>, as well as some medications, such as
thiazide diuretics and carbonic anhydrase inhibitor acetazolamide
(<a href="https://doi.org/10.1007/s13139-020-00637-8">Jochumsen et al., 2020</a>).
<a href="https://doi.org/10.1152/ajpheart.1986.251.5.H1024">Tamaki et al (1986)</a> and
<a href="https://www.ncbi.nlm.nih.gov/pubmed/2090164">Mullani et al (1990)</a> validated RBF
measurements in dogs against <a href="./microspheres.html">microsphere method</a>.
......@@ -198,7 +202,10 @@ The method has also been used in rat model of CNS-induced natriuresis
(<a href="https://doi.org/10.1111/j.1748-1716.1986.tb07933.x">Sj&ouml;quist et al., 1986</a>).</p>
<p>Human renal perfusion studies with [<sup>82</sup>Rb]Rb<sup>+</sup> have been promising
(<a href="https://doi.org/10.1111/1754-9485.12079">Tahari et al., 2014</a>).</p>
(<a href="https://doi.org/10.1111/1754-9485.12079">Tahari et al., 2014</a>).
The high urinary excretion of [<sup>82</sup>Rb]Rb<sup>+</sup> in some patients may hamper the
assessment of RBF (<a href="https://doi.org/10.1007/s13139-020-00637-8">Jochumsen et al., 2020</a>).
</p>
......
---
title: Kidneys
author: Vesa Oikonen
updated_at: 2021-03-29
updated_at: 2021-03-30
created_at: 2017-02-23
tags:
- Kidney
......@@ -652,7 +652,10 @@ effects (<a href="https://doi.org/10.1016/j.kint.2018.11.039">Abumoawad et al.,
<a href="./analysis_82rb.html#RBF">[<sup>82</sup>Rb]Rb<sup>+</sup></a> and
<a href="./analysis_13n-nh3.html#renal">[<sup>13</sup>N]NH<sub>4</sub><sup>+</sup></a>.
Their extraction rate becomes limiting factor at high blood flow, but these tracers can still
provide good perfusion maps for diagnostic purpose.</p>
provide good perfusion maps for diagnostic purpose.
[<sup>82</sup>Rb]Rb<sup>+</sup> is a K<sup>+</sup> analogue, and could be used in K<sup>+</sup>
transport studies; hypokalemia increases urinary excretion of [<sup>82</sup>Rb]Rb<sup>+</sup>
(<a href="https://doi.org/10.1007/s13139-020-00637-8">Jochumsen et al., 2020</a>).</p>
<p><a href="./analysis_h2o_kidney.html">[<sup>15</sup>O]H<sub>2</sub>O</a> has high extraction rate
and as a freely diffusible tracer it can be used in both bolus and steady&#x2010;state imaging
......
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