ref

content/analysis_13n-nh3.html

 ---
 title: Analysis of [N-13]ammonia
 author: Vesa Oikonen, Chunlei Han
-updated_at: 2023-01-28
+updated_at: 2023-03-17
 created_at: 2007-11-21
 tags:
   - Perfusion
@@ -300,12 +300,20 @@ the brain (<a href="http://www.ncbi.nlm.nih.gov/pubmed/36379">Cooper et al., 197
 measurement also in the brain 
 (<a href="http://www.ncbi.nlm.nih.gov/pubmed/818345">Phelps et al., 1976</a>,
 <a href="http://www.ncbi.nlm.nih.gov/pubmed/22147">1977</a> and 
-<a href="http://www.ncbi.nlm.nih.gov/pubmed/7303045">1981</a>), 
+<a href="http://www.ncbi.nlm.nih.gov/pubmed/7303045">1981</a>;
+<a href="https://doi.org/10.1186/s13550-020-00731-0">Egerton et al., 2020</a>), 
 although pH and integrity of the BBB will affect the uptake 
 (<a href="http://www.ncbi.nlm.nih.gov/pubmed/7226451">Raichle and Larson, 1981</a>).
-Late-phase imaging (5-15 min after [<sup>13</sup>N]ammonia injection in rats) 
+Reversible one-tissue compartmental model is the preferred model for [<sup>13</sup>N]ammonia brain 
+PET, and provides K<sub>1</sub> estimates that correlate well with cerebral blood flow assessed
+using <a href="./analysis_h2o_brain.html">radiowater</a>
+(<a href="https://doi.org/10.1186/s13550-020-00731-0">Egerton et al., 2020</a>).</p>
+ 
+<p>Late-phase imaging (5-15 min after [<sup>13</sup>N]ammonia injection in rats) 
 may be suitable for assessment of glutamine synthetase activity
-(<a href="http://www.ncbi.nlm.nih.gov/pubmed/25196365">Momosaki et al., 2015</a>).</p>
+(<a href="http://www.ncbi.nlm.nih.gov/pubmed/25196365">Momosaki et al., 2015</a>).
+However, <a href="https://doi.org/10.1186/s13550-020-00731-0">Egerton et al (2020)</a> could not
+estimate k<sub>3</sub> reliably from 30-min brain PET scans.</p>
 
 
 <h2><a name="tumour">Cancer</a> studies with [<sup>13</sup>N]ammonia</h2>