Commit d1d4e676 authored by Vesa Oikonen's avatar Vesa Oikonen
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title: Analysis of [C-11]L-deprenyl-D2
author: Vesa Oikonen
updated_at: 2021-04-28
updated_at: 2021-04-29
created_at: 2014-05-19
tags:
- MAO B
......@@ -11,14 +11,18 @@ tags:
<h1>Quantification of MAO-B activity with [<sup>11</sup>C]L-deprenyl-D2</h1>
<p>[<sup>11</sup>C]L-deprenyl-D2 (DEP-D) is used to measure the activity of monoamine oxidase B
(MAO-B) in the brain. MAO-B is present in the outer mitochondrial membrane occurring in the brain
<p>[<sup>11</sup>C]L-deprenyl-D2 (DEP-D, [<sup>11</sup>C]DED) is used to measure the activity of
monoamine oxidase B (MAO-B) in <a href="./organ_brain.html">the brain</a>.
MAO-B is present in the outer mitochondrial membrane occurring in the brain
predominantly in glial cells and in serotonergic neurons
(<a href="https://doi.org/10.1007/s11307-005-0016-1">Fowler et al., 2005</a>).
The expression of MAO-B in glial cells is thought to be predominantly, if not exclusively, within
astrocytes (<a href="https://doi.org/10.1007/978-3-7091-9324-2_33">Ekblom et al., 1994</a>;
<a href="https://doi.org/10.1016/j.neuint.2010.10.013">Gulyás et al, 2011</a>), but not
microglia.</p>
microglia.
Astrocytosis is observed in the early stage of <a href="./dis_ad.html">AD</a> pathology, seen as
increased [<sup>11</sup>C]DED uptake
(<a href="https://doi.org/10.1093/brain/awv404">Rodriguez-Vieitez et al., 2016</a>).</p>
<p>MAO-B oxidises amines (for example <a href="./target_dopamine.html">dopamine</a> and
noradrenaline) from both endogenous and exogenous sources.
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