Commit af3cf678 authored by Vesa Oikonen's avatar Vesa Oikonen
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(MAO-B) in the brain. MAO-B is present in the outer mitochondrial membrane occurring in the brain (MAO-B) in the brain. MAO-B is present in the outer mitochondrial membrane occurring in the brain
predominantly in glial cells and in serotonergic neurons predominantly in glial cells and in serotonergic neurons
(<a href="https://doi.org/10.1007/s11307-005-0016-1">Fowler et al., 2005</a>). (<a href="https://doi.org/10.1007/s11307-005-0016-1">Fowler et al., 2005</a>).
It oxidises amines (for example <a href="./target_dopamine.html">dopamine</a>) from both endogenous The expression of MAO-B in glial cells is thought to be predominantly, if not exclusively, within
and exogenous sources. MAO-B is selectively and irreversibly inhibited by L-deprenyl (selegiline). astrocytes (<a href="https://doi.org/10.1007/978-3-7091-9324-2_33">Ekblom et al., 1994</a>), but not
microglia.</p>
<p>MAO-B oxidises amines (for example <a href="./target_dopamine.html">dopamine</a>) from both
endogenous and exogenous sources.
MAO-B is selectively and irreversibly inhibited by L-deprenyl (selegiline).
When the enzyme-substrate complex is formed, the rate-limiting step of MAO-B catalyzed oxidation When the enzyme-substrate complex is formed, the rate-limiting step of MAO-B catalyzed oxidation
creates a highly reactive intermediate, which forms a covalent bond with the enzyme, thus creates a highly reactive intermediate, which forms a covalent bond with the enzyme, thus
irreversibly inactivating it irreversibly inactivating it
...@@ -68,8 +73,9 @@ Reproducibility in test-retest studies was improved by using &lambda;k<sub>3</su ...@@ -68,8 +73,9 @@ Reproducibility in test-retest studies was improved by using &lambda;k<sub>3</su
k<sub>3</sub> (<a href="https://doi.org/10.1016/s0969-8051(99)00088-8">Logan et al., 2000</a>).</p> k<sub>3</sub> (<a href="https://doi.org/10.1016/s0969-8051(99)00088-8">Logan et al., 2000</a>).</p>
<p>For instance, Fowler et al <a href="https://doi.org/10.1111/j.1471-4159.1988.tb01121.x">1988</a> <p>For instance, Fowler et al <a href="https://doi.org/10.1111/j.1471-4159.1988.tb01121.x">1988</a>
and <a href="https://pubmed.ncbi.nlm.nih.gov/7790952/">1995</a>) and and <a href="https://pubmed.ncbi.nlm.nih.gov/7790952/">1995</a>),
<a href="https://doi.org/10.1016/s0969-8051(99)00088-8">Logan et al (2000)</a> have estimated the <a href="https://doi.org/10.1016/s0969-8051(99)00088-8">Logan et al (2000)</a>, and
<a href="https://doi.org/10.1007/s00259-016-3510-6">Sturm et al., 2017</a> have estimated the
three-compartment model parameters using traditional nonlinear least squares approach. three-compartment model parameters using traditional nonlinear least squares approach.
In a addition, <a href="#GA">graphical analysis</a> methods have been used.</p> In a addition, <a href="#GA">graphical analysis</a> methods have been used.</p>
...@@ -334,7 +340,7 @@ the cluster value (<a href="https://doi.org/10.4161/epi.21976">Shumay et al., 20 ...@@ -334,7 +340,7 @@ the cluster value (<a href="https://doi.org/10.4161/epi.21976">Shumay et al., 20
<br><hr> <br><hr>
<h2>References:</h2> <h2>Literature:</h2>
<p>Arakawa R, Stenkrona P, Takano A, Nag S, Maior RS, Halldin C. <p>Arakawa R, Stenkrona P, Takano A, Nag S, Maior RS, Halldin C.
Test-retest reproducibility of [<sup>11</sup>C]L-deprenyl-D<sub>2</sub> binding to MAO-B in Test-retest reproducibility of [<sup>11</sup>C]L-deprenyl-D<sub>2</sub> binding to MAO-B in
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