Commit 94740583 authored by Vesa Oikonen's avatar Vesa Oikonen
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---
title: Blood brain barrier
author: Vesa Oikonen
updated_at: 2020-01-28
updated_at: 2021-03-30
created_at: 2016-06-04
tags:
- BBB
......@@ -55,6 +55,13 @@ increased tracer uptake in the brain implied decreased P-gp function.
[<sup>11</sup>C]D617 is also a P-gp substrate
(<a href="https://doi.org/10.1021/acschemneuro.7b00086">Raaphorst et al., 2017</a>).</p>
<p>In drug development, drug molecules can be labelled using positron emitting isotope to assess
their <a href="./drug_biodistribution.html">bio&shy;distribution</a> and the impact of transporters
on the brain exposure of the drugs
(<a href="https://doi.org/10.2967/jnumed.115.164350">Pottier et al., 2016</a>;
<a href="https://doi.org/10.1016/j.pharmthera.2018.04.006">Tournier et al., 2018</a>).</p>
<h2>Astrocytes in BBB</h2>
<p>Astrocytes are the most abundant cell type in <a href="./organ_brain.html">the brain</a>, and
......
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