Commit 45707e5e authored by Vesa Oikonen's avatar Vesa Oikonen
Browse files

added CL

parent 75a0049f
Pipeline #38874 passed with stages
in 1 minute and 32 seconds
---
title: FUR
author: Vesa Oikonen
updated_at: 2019-12-31
updated_at: 2021-03-26
created_at: 2007-11-01
tags:
- FUR
......@@ -33,8 +33,13 @@ Ishizu et al. <a href="https://www.ncbi.nlm.nih.gov/pubmed/8014665">1994</a> and
<p>Thus the unit of <em>FUR</em> is min<sup>-1</sup>
(<a href="https://www.ncbi.nlm.nih.gov/pubmed/7699475">Thie, 1995</a>), the same as for
<a href="./model_ki.html"><em>K<sub>i</sub></em></a>.
<em>FUR</em> can be calculated from a <a href="./image_late-scan.html">single late PET scan</a>,
<a href="./model_ki.html"><em>K<sub>i</sub></em></a> , if both tissue and plasma concentrations are
given per mL (=cm<sup>3</sup>).
If <em>FUR</em> is multiplied by organ volume, the result represents organ's net plasma clearance
(<em>CL</em> ) with units of (mL plasma)&times;min<sup>-1</sup>.</p>
<p><em>FUR</em> can be calculated from a <a href="./image_late-scan.html">single late PET scan</a>,
like <em><a href="./model_suv.html">SUV</a></em>, but <a href="./input_sampling.html">blood
sampling</a> from the injection to the scan time is required.</p>
......@@ -49,7 +54,7 @@ especially in analysis of cardiac PET studies. This is discouraged, because the
to the extent that at large <em>T</em> (late time after injection) the effective distribution volume
term in Patlak analysis is not important (y axis intercept is assumed to be 0).
<em>FUR</em> and <em><a href="./model_suv.html">SUV</a></em> are proportional,
related by plasma clearance rate and a dimensionless initial distribution volume
related by total plasma clearance rate and a dimensionless initial distribution volume
(<a href="https://www.ncbi.nlm.nih.gov/pubmed/7699475">Thie, 1995</a>).</p>
......
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