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Commit 426b52f7 authored by Vesa Oikonen's avatar Vesa Oikonen
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title: Analysis of [<sup>18</sup>F]DPA-714
author: Vesa Oikonen
updated_at: 2020-01-17
updated_at: 2021-06-07
created_at: 2009-02-27
tags:
- Inflammation
......@@ -16,7 +16,9 @@ tags:
<p>DPA-714 (and previous molecule DPA-713) is a selective ligand for the
<a href="./target_tspo.html">translocator protein (TSPO)</a>, formerly known as
peripheral benzodiazepine receptor (PBR).</p>
peripheral benzodiazepine receptor (PBR). In human brain [<sup>11</sup>C]DPA-713 has much higher
specific binding than the most used TSPO radioligand [<sup>11</sup>C]-(<em>R</em>)-PK11195
(<a href="https://doi.org/10.1177/0271678X17699223">Kobayashi et al., 2018</a>).</p>
<p><a href="https://doi.org/10.2967/jnumed.107.046151">James et al. (2008)</a> performed
[<sup>18</sup>F]DPA-714 PET studies with rats and a baboon (<em>P. hamadryas</em>).
......@@ -40,9 +42,8 @@ monkeys, healthy and with induced neurodegeneration.
Results also support the usefulness of [<sup>18</sup>F]DPA-714.
Saba et al. (<a href="https://doi.org/10.1111/adb.12548">2017</a>) studied baboons, and noticed
increased binding after acute alcohol exposure.
In human brain [<sup>11</sup>C]DPA-713 has much higher specific binding than
[<sup>11</sup>C]-(<em>R</em>)-PK11195
(<a href="https://doi.org/10.1177/0271678X17699223">Kobayashi et al., 2018</a>).</p>
In rat model, nalmefene prevents the increase of [<sup>18</sup>F]DPA-714 binding caused by binge-like
ethanol exposure (<a href="https://doi.org/10.1111/adb.12962">Tournier et al., 2021</a>).</p>
<p>Longitudinal [<sup>18</sup>F]DPA-714 PET imaging in transgenic mouse model of
<a href="./dis_ad.html">Alzheimer's disease</a> could demonstrate increased neuroinflammation
......@@ -57,6 +58,12 @@ chronic neuroinflammation in regions remote from the initial site of injury
[<sup>124</sup>I]DPA-713 could be used for imaging macrophage-associated inflammation
(<a href="https://doi.org/10.2967/jnumed.117.207431">Foss et al., 2018</a>).</p>
<p>TSPO ligands shown promise in detecting <a href="./organ_bat.html">brown adipose tissue</a>
because of its high content of <a href="./mitochondria.html#TSPO">mitochondria</a>, and
[<sup>18</sup>F]DPA-714 has shown promise in this respect
(<a href="https://jnm.snmjournals.org/content/58/supplement_1/480">Wang et al., 2017</a>;
<a href="https://doi.org/10.1080/21623945.2020.1814546">Niu et al., 2020</a>).</p>
<h2>Metabolism</h2>
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